Analysis of cell immune regulation features in recurrent ovarian endometriosis

BACKGROUND: The prevalence of endometriosis among women reproductive age and the complexity choosing methods for its effective treatment necessitate study clinical morphological features ovarian in recurrent course, as well search available informative diagnostic prognostic markers which allow identifying risk groups relapse form prevention methods. Endometriomas have a recurrence rate 5055 % after treatment.
 AIM: aim this was to conduct comparative analysis cell immune regulation endometriosis.
 MATERIALS AND METHODS: We studied data, value peripheral immunocompetent blood cells, immunohistochemical data 196 patients operated on endometrioid cysts, including 45 with course disease 151 without relapse. Monoclonal mouse antibodies T helpers (CD4), killers (CD8), B lymphocytes (CD20), macrophages (CD68) were used examination surgical material. Immunological performed by flow cytometry assessment helper lymphocyte, killer lymphocyte subpopulations their ratios.
 RESULTS: cysts 22.96%. Most (48.87%) relapsed 34 years first operation. In endometrioma, we more often detected complaints dyspareunia, dysmenorrhea, primary infertility history operations uterine appendages unrelated anamnesis, third degree pathological process. During examination, glandular-cystic variant morphologically active lesions compared relapse-free course. Cytotoxic (CD8) shown be predominant subpopulation cells found inflammatory infiltrate cytogenic stroma cyst capsule. More them material both second count significantly higher capsule than cases (CD4) only an already diagnosed recurrence. endometrioma revealed increase total population due helpers, number per microliter exceeded reference values.
 CONCLUSIONS: An free stromal foci indicates importance hyperreactivity autoimmune mechanism chronization progression disease.